APFID

Home > Latest News on ID > Infectious Disease News
LOGIN
[News from the Scientific Literature] Pediatric pneumonia death caused by community-acquired methicillin-resistant Staphylococcus aureus, Japan
Date: 2008-10-02   Read: 99781

Pediatric pneumonia death caused by community-acquired methicillin-resistant Staphylococcus aureus, Japan

Ito T et al., EID 2008 Aug;14(8):1312-1314   

Summary (Summarized from the article) 

There has been an increasing concern on community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) carrying Panton-Valentine leukocidin (PVL) genes although the role of PVL in the pathogenesis of staphylococcal infections is controversial. Several types of CA-MRSA clones exist, e.g., CA-MRSA belonging to multilocus sequence type (ST) 1 (USA400) and ST8 (USA300), which have been major clones in North America (recently, USA300 is becoming more prominent); CA-MRSA belonging to ST80, which has been a major clone in Europe; and CA-MRSA belonging to ST30, which is distributed worldwide, including Japan. To date, all cases of PVL-positive CA-MRSA infections officially reported in Japan were caused by strains belonging to ST30 and MRSA carrying the PVL gene (ST30) comprises 0.1% of MRSA isolated in hospitals in Japan.
A 16-month-old boy admitted to the hospital died on day 10 after admission. Molecular characterization of MRSA isolated (strain NN32) from the blood showed that strain NN32 was positive for PVL, belonging to ST30:spa 19:staphylococcal cassette chromosome mec (SCCmec) IVa, and was resistant to only β-lactam antimicrobial agents. The molecular characteristics of strain NN32 were similar to those of strain NN1, which is a PVL-positive CA-MRSA strain isolated in Japan belonging to ST30, except for SCCmec IV subtypes. Moreover, pulsed-field gel electrophoresis (PFGE) patterns and the PVL gene sequences of the strains NN32 and NN1 were identical. This article reports a fatal case of pediatric pneumonia and septic shock from CA-MRSA in Japan.

 

Next [News from the Scientific Literature] Growth and geographic variation in hospitalizations with resistant infections, United States, 2000-2005. 2008-12-17 99888
Previous [News from BMJ: September 19, 2008] We are facing a global pandemic of antibiotic resistance 2008-10-02 98180
޴ٷΰ ΰ