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Panton-Valentine leukocidin is not a virulence determinant in murine models of CA-MRSA disease.
JID 2008, 198(8):1166-1170
Date: 2008-10-02   Read: 214038

The Journal of Infectious Diseases 2008;198(8):1166-1170

Panton-Valentine Leukocidin Is Not a Virulence Determinant in Murine Models of Community-Associated Methicillin-Resistant Staphylococcus aureus Disease.

Juliane Bubeck Wardenburg1,2, Amy M. Palazzolo-Ballance3, Michael Otto3, Olaf Schneewind1, Frank R. DeLeo3

1Departments of 1Microbiology and 2Pediatrics, University of Chicago, Chicago, Illinois; 3Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana

Increases in the incidence and severity of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections have spawned efforts to define unique virulence properties among prevalent strains. Panton-Valentine leukocidin (PVL), a pore-forming cytotoxin, has garnered attention because of its epidemiologic association with CA-MRSA. Using both the clinical isolate LAC, which is representative of the epidemic USA300 strain, and its isogenic PVL-negative strain in murine models of staphylococcal skin infection and pneumonia, we expanded upon recent studies by assessing the contribution of PVL in the genetic background of BALB/c mice. The data presented in this report support the observation that PVL does not contribute to the pathogenesis of staphylococcal infection of mice.

Next The role of virulence determinants in community-associated MRSA pathogenesis.
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